Based on the results of network toxicology and network pharmacology, we found that the mechanism by which LA ameliorates peripheral neuropathy induced by nab-PTX might be associated with multiple signaling pathways such as PI3K-Akt signaling pathway, AGE-RAGE signaling pathway in diabetic complications, TNF signaling pathway and the IL-17 signaling pathway. Here, AKT1 is linked to peripheral neuropathy.