Emerging evidence further positions Tregs as central mediators of tissue repair, suppressing the inflammatory response by producing anti‐inflammatory cytokines such as IL‐10, TGF‐β, and IL‐35 (67, 68), with their local presence demonstrably attenuating experimental periodontitis severity and limiting alveolar bone destruction (69–71). This evidence concerns the gene TGFB1 and periodontitis.