XPO1 and acute myeloid leukemia: We constructed a zebrafish xenograft models using si-CRM1 MV4-11, NC-MV4-11, and leukemia cells extracted from relapsed AML patients, and the fluorescence intensity of leukemia cells in zebrafish CHT was used to evaluate the therapeutic effect in vivo (Supplementary Figure S2). We firstly treated the zebrafish embryos with xenografts of NC-MV4–11 and si-CRM1 MV4–11 with DNR to compared the drug sensitivity of leukemia cells at the CHT to DNR.