VEGFA signaling through these receptors activates downstream pathways that drive endothelial cell proliferation, migration, and tube formation, all of which are critical for new blood vessel formation.Additionally,FN1-integrin,VEGFA_KDR and VEGFA-NRP1 interactions could serve as potential signals associated with poor prognosis for renal cell carcinoma (RCC)bone metastasis (71, 72) (Figures 6c ,e, f). Here, FN1 is linked to hereditary clear cell renal cell carcinoma.