TIGIT and neoplasm: In the tumor group, three receptor-ligand pairs were found to be enriched, namely the COL4A2-integrin α1β1 complex,NECTIN2-TIGIT and CXCL11-CXCR3.The COL4A2-integrin α1β1 complex may influence the adhesion and migration of CD8+ T cells, facilitating their migration toward the tumor site and promoting anti-tumor immune responses.