Macrophages and EC5 exhibit enrichment of eight receptor-ligand pairs, including FN1_integrin,VEGFA_NRP1,ADM_RAMP3,COL6A2_integrin_α1β1_complex,VEGFA_FLT1,VEGFA_KDR,CCL2_ACKR1,SPP1_integrin_α9β1_complex, SEMA4A_PLXND.Within the tumor microenvironment, the activation of PPARG on EC may modulate their metabolic state and function, potentially influencing vascular permeability and the tumor’s nutrient supply. Here, RAMP3 is linked to neoplasm.