IFNB1 and neoplasm: Subsequent Gene Ontology (GO) analysis also unveiled enriched pathways associated with antigen processing and presentation, response to interferon-beta, and immune system processes in EC4, suggesting that EC4 may represent an endothelial cell phenotype actively engaged in responding to inflammatory cell infiltration into the tumor.EC5 demonstrated highly expressed pathways related to angiogenesis, response to hypoxia, and positive regulation of endothelial cell proliferation.