FN1 and renal cell carcinoma: VEGFA signaling through these receptors activates downstream pathways that drive endothelial cell proliferation, migration, and tube formation, all of which are critical for new blood vessel formation.Additionally,FN1-integrin,VEGFA_KDR and VEGFA-NRP1 interactions could serve as potential signals associated with poor prognosis for renal cell carcinoma (RCC)bone metastasis (71, 72) (Figures 6c ,e, f).