In contrast,EC5 and EC6 subclasses exhibited conserved pro-angiogenic signatures encompassing established vascular morphogenesis regulators (CD34,AQP1) and emerging angiocrine signaling components (RAMP2/3,CRIP2,PCDH17) (Figures 3j, k),consistent with previous reports on tumor neovascularization dynamics (31, 35). Here, RAMP2 is linked to neoplasm.