Several receptor-ligand pairs were enriched, Including CLU-TREM2,CCL14-CCR1,APP-TREM2,SEMA3F-NRP2,CD93-IFNGR1 and CCL23-CCR1.The CLU-TREM2 interaction might modulate the activation state of macrophages and promote their polarization toward a tumor-associated macrophage (TAM) phenotype. Here, CLU is linked to neoplasm.