CD274 and neoplasm: (Reviewer 5 Q4) FUS can overcome this limitation and enhance tumor sensitivity to drugs through the following mechanisms: first, FUS can transiently open the tight junctions of the BBB via mechanical cavitation, allowing macromolecular agents such as immune checkpoint inhibitors (anti–PD-1/PD-L1 antibodies) and cell-based therapies (e.g., CAR-T cells) to cross the BBB, thereby significantly increasing the infiltration of immune effector cells into the central nervous system (92).