Defined by iron-dependent lipid peroxidation (LPO) and regulated by key molecules such as glutathione peroxidase 4 (GPX4) and the cystine/glutamate antiporter system Xc− (4), ferroptosis has been implicated in cardiomyocyte death during infarction and in multiple cardiovascular diseases (5). This evidence concerns the gene GPX4 and cardiovascular disorder.