CD274 and hypothyroidism: In another meta-analysis encompassing nearly 3,000 treated patients, the most frequently targeted organs by irAEs during programmed death-1 (PD-1) or programmed death-ligand 1 (PD-L1) inhibition were the skin (pruritus 10%, rash 11%), the gastrointestinal tract (diarrhea 11%), and the thyroid (hypothyroidism 7%) (8).