Primary AI results in a severe deficiency in both cortisol and saline corticosteroid (aldosterone) secretion, which manifests as low cortisol with high ACTH, and characteristic symptoms include malaise, hypotension, nausea and vomiting, hyponatremia, hyperkalemia, and hyperpigmentation of the skin and mucous membranes. The gene discussed is POMC; the disease is Hyperkalemia.