Pituitary inflammation leads to insufficient ACTH secretion (incidence up to 75%), which in turn causes atrophy of the adrenocortical zona fasciculata and decreased cortisol synthesis, manifesting as hypocortisolism with low/normal ACTH, often coexisting with other anterior pituitary hormone deficiencies; recovery of the ACTH axis function is rare, and long-term glucocorticoid replacement is usually required. This evidence concerns the gene POMC and hypopituitarism.