Interestingly, Elovl5, Elongase of PUFAs C3 and C6 polyunsaturated, Scd1 and Scd2, desaturases involved in synthesis of monounsaturated FAs and Acaca enzyme involved in rate limiting step in FA biosynthesis are downregulated in both AD/cKO and cKO MOL. This evidence concerns the gene ACACA and Alzheimer disease.