As expected, we observed a marked depletion of Fus expression in MOL and a moderate reduction in Fus in committed oligodendrocyte precursors (COP), newly formed oligodendrocytes (NFOL), and myelin-forming oligodendrocytes (MFOL), in both cKO and AD/cKO compared to WT and AD mice (Fig. 7C). This evidence concerns the gene FUS and Alzheimer disease.