APP and Alzheimer disease: The AppNL-G-F knockin mouse carries human AD mutations under the endogenous App promoter regulation and, unlike other mouse models, is not over-expressed and in the Fusfl/fl/Cnpcre/+, unlike other hypermyelinating mouse lines, the increase in myelin is developmentally regulated and additional myelin deposition does not continue unchecked past the completion of myelination17.