Remarkably, oxidative phosphorylation genes of mitochondrial complex 1 (Ndufa1, 3 and Ndufb5, mt-Nd5), antioxidant (SOD1, Gstp1, Gss), electron transport chain are exclusively upregulated in the AD/cKO vs. AD but not in the cKO vs. WT (Fig. 7F). The gene discussed is NDUFB5; the disease is Alzheimer disease.