TREM2 and Alzheimer disease: TREM2+/Iba1+ cells were statistically higher at the niche of the AD/cKO CA1 vs. AD at 12 (Fig. 2 E, F, p=0.009) and 16 months of age (Fig. 2 E, F, p=0.0003), while they were increased only at 16 months in the cortex (Fig. 2 E, F, p=0.0002) and mPFC (SFig. 4C p=0.0025) of the AD/cKO vs. AD.