While the cKO and AD/cKO had greater MBP expression relative to WT and AD, consistent with Fus depletion driven increase in myelin thickness, the increase was statistically significant only in the cKO vs. WT at 6 (Fig.4 A, B, C, p=0.004) and 12 months (Fig. 4A B C, p=0.019). This evidence concerns the gene MBP and Alzheimer disease.