TREM2 and Alzheimer disease: TREM2 microglia limit amyloid deposition31, however, a reduction of plaque burden is present only in the AD/cKO hippocampus but not in cortex and mPFC, uncoupling plaque burden from synaptic structure preservation and rather suggests an effect of TREM2+ secreted anti-inflammatory cytokines34,65,66 and TREM2 mediated neuroprotection67.