CDH1 and neoplasm: Pommier et al. demonstrated that disseminated tumor cells in the liver are subject to major histocompatibility complex class I (MHC-I)–restricted T-cell killing; surviving cells are selected for an immune-evasive, quiescent state characterized by low/absent MHC-I, loss of E-cadherin and cytokeratin-19 and chronic, unresolved endoplasmic reticulum (ER) stress signaling (Pommier et al., 2018).