Similarly, Klotho, Uromodulin and BTP also exhibited very high AUCs (>0.98) in CKD group, highlighting their potential in early detection markers and these biomarkers show highly effective for the early detection of CKD, particularly when compared with AUC of AKI group Bansal A et al. has reported that abnormal blood levels of BTP, NGAL, kidney injury molecule-1 (KIM-1) and ADMA are associated with abnormal renal function.39 This evidence concerns the gene LCN2 and chronic kidney disease.