Neutrophil gelatinase-associated lipocalin (NGAL) is one of the important biomarkers expressed in renal tubular cells and is found in urine and plasma at low concentrations.13 Beta-2 Microglobulin (B2M) is a small protein on the surface of all nucleated cells in the body.14 Identifying highly sensitive and specific biomarkers for the early detection of CKD and their subsequent impact on enhancing patient prognosis represents a significant and unresolved requirement within the medical field and is the basic aim of our study. The gene discussed is B2M; the disease is chronic kidney disease.