Neutrophil gelatinase-associated lipocalin (NGAL) is one of the important biomarkers expressed in renal tubular cells and is found in urine and plasma at low concentrations.13 Beta-2 Microglobulin (B2M) is a small protein on the surface of all nucleated cells in the body.14 Identifying highly sensitive and specific biomarkers for the early detection of CKD and their subsequent impact on enhancing patient prognosis represents a significant and unresolved requirement within the medical field and is the basic aim of our study. This evidence concerns the gene LCN2 and chronic kidney disease.