Moreover, PASS (P < 0.001) and vWF were indicated by multi-factor logistic regression analysis results: Ag (P < 0.001), PT (P < 0.001), ATIII (P < 0.001), D-D (P < 0.001) and Ca (P < 0.001) were independent risk factors predicting the severity of AP. This evidence concerns the gene SERPINC1 and alkaline phosphatase measurement.