Multifactorial logistic regression analysis indicated that PASS (P < 0.001), vWF:Ag (P < 0.001), PT(P< 0.001), ATIII(P< 0.001), D-D (P < 0.001) and AMD Ca (P < 0.001) were independent risk factors for predicting the severity of AP (Table III). This evidence concerns the gene VWF and age-related macular degeneration.