Regression analysis showed that BMI, F%, FM, FPG and insulin are independent predictors of pre-D risk (p <0.001); moreover, crosstabs revealed the assessment of cardiovascular risk which revealed significant high odds ratios in pre-D subjects with hypertension (OR = 31.7), hyperglycemia (OR = 40), metabolic syndrome (OR = 35), smoking (OR = 55) and obesity (OR = 64.7). The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.