This study presents a novel targeted nanomedicine for pancreatic cancer imaging and local magnetic hyperthermia therapy (MHT): urokinase plasminogen activator receptor (uPAR)-targeted, indocyanine green (ICG)-conjugated ferrimagnetic vortex iron oxide (FVIOs) nanorings (u-I-FVIOs). This evidence concerns the gene PLAUR and pancreatic neoplasm.