THBS1 and chronic liver failure: Thrombospondin-1 (THBS1) is a secreted glycoprotein found mainly in blood and extracellular matrix (ECM), occupying an important position in several biological processes (BP) of RILI, including promoting hepatic inflammatory response, mediating acute and chronic liver failure, and fibrin deposition (Gutierrez and Gutierrez, 2021; Hassan et al., 2022).