In CLP-induced ALI models, luteolin (20 mg/kg, i.p.)reduced inflammatory cytokines (IL-1β, IL-6, TNF-α, IL-17A) in serum and BALF, decreased neutrophil infiltration and myeloperoxidase (MPO) activity, and alleviated pulmonary edema, as indicated by decreased W/D ratios. The gene discussed is TNF; the disease is acute respiratory distress syndrome.