We found that after BPS intervention, the protein expression levels of fibrosis indexes such as Collagen I, Collagen IV, FN, α-SMA, and TGF-β1 in the renal tissues of db/db mice decreased, indicating that BPS can reduce the protein expression of ECM, inhibit ECM deposition, and thus delay the fibrotic progress of DN. Here, TGFB1 is linked to liver dysplastic nodule.