It is reported that knocking out the NLRP3 gene can effectively inhibit the infiltration of macrophages in the kidneys of DM rats, reduce the protein expression of TGF-β1 and CTGF, improve glomerular lesions in mice, and reduce the protein expression of FN, Collagen I, and Collagen IV(Wu et al., 2018). This evidence concerns the gene FN1 and diabetes mellitus.