We found that after BPS intervention, the protein expression levels of fibrosis indexes such as Collagen I, Collagen IV, FN, α-SMA, and TGF-β1 in the renal tissues of db/db mice decreased, indicating that BPS can reduce the protein expression of ECM, inhibit ECM deposition, and thus delay the fibrotic progress of DN. The gene discussed is ACTA1; the disease is liver dysplastic nodule.