Different locations produced AG with different anti-heart failure propertiesRg3, Rg5, Rg6, malic acid, quinic acid, F11 were the pharmacodynamic markers responsible for anti-heart failureRg3: ↓FGF1, STAT3; Rg5: ↓FGF2; Rg6: ↓FGF2, VEGFA; F11: ↓FGF1, VEGFA, FGF2. Here, FGF2 is linked to heart failure.