Existing studies have confirmed that the miR-21-5p/PTEN regulatory axis is extensively involved in the occurrence and development of various cancers (Tang et al., 2018; Yan et al., 2020), and targeted inhibition of miR-21 expression has become a potential novel target in the field of tumor therapy (Jinhua et al., 2022). The gene discussed is PTEN; the disease is neoplasm.