Combined effect of eleven studies (111 animal) investigating the effect of MSC-sEVs on TNF-α showed that MSC-sEVs are potent to reduce the TNF-α level compared to sepsis induced animals with no interventions (SMD: −5.23, 95% CI: −7.05, −3.41, P < 0.001; I2 = 78.7%; P < 0.001) (Figure 3A). Here, TNF is linked to Sepsis.