We observed that prediabetic mice presented increased levels of inflammatory factors, including IL-1β, IL-6, LPS, NF-κB, and TNF-α, in both the circulation and ileum, and these effects were inhibited by liraglutide treatment (Figures 2A–J); however, there was no significant difference in the serum IL-1β concentration between the prediabetes and prediabetes + Lira groups (n = 10 per group). This evidence concerns the gene TNF and prediabetes syndrome.