To investigate the mechanism by which periodontitis impairs the intestinal barrier, we used our previous unbiased transcriptome of the colon tissue (Wang et al., 2023a) to perform KEGG pathway enrichment analysis and found that the NF-κB signaling pathway was markedly enriched in the ligature-DSS group compared with the DSS group (Figure 2C). The gene discussed is NFKB1; the disease is periodontitis.