In the exploration of the mechanism by which periodontitis impairs the intestinal barrier, the KEGG pathway enrichment analysis showed that IL-17 signaling appeared as highly enriched as NF-κB signaling (Figure 2C), indicating a strong transcriptional footprint of the Th17/IL-17 axis in the dual periodontitis-colitis model. Here, NFKB1 is linked to periodontitis.