TTN and myasthenia gravis: In the context of aberrant immune responses against muscle tissue, Titin-Ab may erroneously target and damage muscle cells, leading to structural disruption (18); Titin-Ab specifically recognizes the MGT-30 antigen, which is encoded by the cDNA sequence at the A/I junctional region of the titin protein, this interaction interferes with normal neuromuscular transmission and sarcomere assembly, thereby exacerbating the severity of MG (19).