IGHE and eosinophilic esophagitis: ,49 Although IgE-mediated food allergy and EoE can co-exist (those with IgE-mediated food allergy can have a 9.1 fold higher risk of subsequent EoE),27 the pathophysiology of EoE (see statement #1) is that of delayed non-IgE-mediated food responses, providing a plausible mechanistic rationale for why skin prick and sIgE testing should be reserved for confirmation of potentially anaphylactic IgE-mediated food allergy and not EoE food triggers.130