RAB18 and allergic disease: In terms of safety, some studies have reported that high doses of garlic may cause allergic reactions, changes in platelet function and coagulation, as well as gastrointestinal discomfort (30), which may be attributed to the sulfur-containing compounds generated by high levels of allicin, which can bind to RAB18 protein and create a copper-enriched microenvironment, thereby inducing cuproptosis in hepatic stellate cells (31).