After adjusting for gender, age, hypertension, diabetes, stroke, CHD, NYHA classification, drinking status, smoking status, LVEF, neutrophil count, monocyte count, RBC, PLT, AST, Cr, BUN, UA, FPG, and NT-proBNP, our results demonstrated a significant inverse association between the CALLY index and short-term prognosis in ADHF patients, with superior risk stratification capability compared to the PNI. This evidence concerns the gene NPPB and hypertensive disorder.