Sperm from infertile men show altered PRM1/PRM2 ratio or undetectable PRM2 in mature sperm (Sharma and Agarwal, 2011), with a PRM1/PRM2 >1 ratio (Carrell and Liu, 2001) and embryos derived from sperm deficient in PRM2 had their development affected (Cho et al., 2003). This evidence concerns the gene PRM2 and Infertility.