In consistent with this finding, an analysis of stool samples from CGD patients reveals significant abundances in pathways such as isopropanol biosynthesis, NAD salvage, allantoin degradation, propanediol degradation, and glycerol degradation.35 These alterations in the metabolic profiles of the microbiomes from CGD patients resemble those seen in our MPO knockout mice and thus suggest that similar oxidant-dependent events lead to similar alterations in metabolic pathways and pathogenic mechanisms in both settings. Here, MPO is linked to chronic granulomatous disease.