Investigating and understanding the association between serum IGF-1 levels and glycemic control will improve patient outcomes and facilitate the development of targeted interventions. The aim of this study was to investigate serum IGF-1 levels in controlled and uncontrolled T2DM within the geriatric population and evaluate its potential as a biomarker for metabolic control in this vulnerable group. This evidence concerns the gene IGF1 and type 2 diabetes mellitus.