INS and diabetes mellitus: Similarly, pooled analyses from DETECT (Diabetes and Cardiovascular Risk Evaluation: Targets and Essential Data for Commitment of Treatment) and SHIP (Studying the Hurdles of Insulin Prescription) cohorts (n=7,777) demonstrated that IGF-1 extremes (below 10th or above 90th percentile) increased diabetes risk compared to mid-range concentrations, confirming a U-shaped pattern [20].