Suda et al. (2016) observed markedly lower IGF-1 in Japanese patients with very poorly controlled T2DM (HbA1c ≥12%) compared to those with HbA1c <12%, and noted that improvements in HbA1c during follow-up were paralleled by rises in IGF-1 [16]. The gene discussed is IGF1; the disease is type 2 diabetes mellitus.