CRM: circumferential resection margin; EMVI: extramural vascular invasion; IQR: interquartile range; LC: long course (regarding radiation regimen); NA: not available; RCT: radiochemotherapy; SC: short course (regarding radiation regimen); TNT: total neoadjuvant therapy; UICC: Union for International Cancer Control; TRG: tumor regression grading; DPD: dihydropyrimidine dehydrogenase; 5-FU: fluorouracil; CAPOX: capecitabine and oxaliplatin; FOLFIRINOX: folinic acid, 5-FU, irinotecan, and oxaliplatin; FOLFOX: folinic acid, 5-FU, and oxaliplatin. Here, DPYD is linked to neoplasm.