Analytically, the patient had no leukocytosis or elevated C-reactive protein (CRP); the serum protein electrophoresis had no monoclonal peaks, with an erythrocyte sedimentation rate (ESR) of 83 mm/h and a consistent increase in creatine kinase between 3283 and 4230; serology for Cytomegalovirus (CMV), Epstein-Barr virus (EBV), hepatitis, syphilis, and mononucleosis was negative; IGRA was negative; aldolase was 103.5; angiotensin converting enzyme (ACE) was normal. The gene discussed is ACE; the disease is syphilis.