Abbreviations: AF = atrial fibrillation, ASCVD = atherosclerotic cardiovascular disease, CKD = chronic kidney disease, CV = cardiovascular, HF = heart failure, HFpEF = heart failure with preserved ejection fraction, HFrEF = heart failure with reduced ejection fraction, MACE = major adverse cardiovascular events, T2DM = type 2 diabetes mellitus, SGLT-2 = sodium-glucose cotransporter-2. The gene discussed is SLC5A2; the disease is heart failure.