Amylin RA: amylin receptor agonist; CKD: chronic kidney disease; CV: cardiovascular; GCG RA: glucagon receptor agonist; GIP RA: glucose‐dependent insulinotropic peptide receptor agonist; GLP‐1 RA: glucagon‐like peptide‐1 receptor agonist; GLP‐2 RA: glucagon‐like peptide‐2 receptor agonist; MASLD: metabolic dysfunction‐associated steatotic liver disease; MASH: metabolic dysfunction‐associated steatohepatitis; OA: osteoarthritis; T2D/T2DM: type 2 diabetes mellitus. The gene discussed is GCG; the disease is chronic kidney disease.