TNF and neoplasm: This gene contributes to the unique transcriptionalprofile of neutrophils, which helps in identifying neutrophils within the tumour microenvironment [80].Previous studies have demonstrated that the expression of Hist1h2bc is increased in the ageing retina [81].Another study showed that a reduction in the protein expression of HIST1H2BC, which possesses antibacterial properties, can enhance thecapacity of TNF-alpha (gene: TNF) to induce the upregulation of genes linked with inflammation.