Dysregulated cytokine signaling is a shared feature in dermatological and psychiatric conditions with elevated cytokines IL-4 and IL-13 in AD associated with depressive symptoms,92, 93, 94, 95 IL-17A has been linked to antidepressant resistance96 and TNF-α and IL-23 elevation with generalized anxiety disorder.97 This evidence concerns the gene TNF and Alzheimer disease.