MAN1B1 and obesity disorder: Our proband has unique facial features (small forehead, wide eye distance, small bilateral eye slits, low nasal bridge, protruding nose, short stature, small chin, large ears, short neck), delayed critical intelligence, trunk obesity, abnormal coagulation function, abnormal electroencephalogram, etc., which are similar to the clinical manifestations of CDG-II caused by MAN1B1 deficiency reported in the literature.