In this study, 214 SNPs in the PIP2 pathway genes showed P < 0.05 of POE on T2D, covering PRKCQ, DGKB, MGLL, PRKCE, DGKH, DAGLB, ITPR1, ITPR2, DGKQ, PRKCH, RASGRP2, DGKD, and DGKG. This evidence concerns the gene PRKCQ and type 2 diabetes mellitus.