proposed an association between a heterozygous missense variant p.Leu59Arg in LMNA and Malouf syndrome (dilated cardiomyopathy with hypergonadotropic hypogonadism), based on two unrelated patients with dysgenetic ovaries and onset of cardiomyopathy at ages 12 and 17 (43). Here, LMNA is linked to Dilated cardiomyopathy - hypergonadotropic hypogonadism.