proposed an association between a heterozygous missense variant p.Leu59Arg in LMNA and Malouf syndrome (dilated cardiomyopathy with hypergonadotropic hypogonadism), based on two unrelated patients with dysgenetic ovaries and onset of cardiomyopathy at ages 12 and 17 (43). The gene discussed is LMNA; the disease is Hypergonadotropic hypogonadism.