In contrast, a male patient with musculoskeletal disorders, hyperlipidemia, and neurological disorders, no hypertension, insulin-only therapy, an HbA1c of 7%, FPG of 6–7 mmol/L, BMI of 24 kg/m2, and DBP of 82 mmHg has an estimated PDPN risk of 99%. This evidence concerns the gene INS and nervous system disorder.