SLC5A1 and autosomal dominant polycystic kidney disease: It has been proposed that the statistically significant increase in height-adjusted TKV following SGLT2i initiation may result from increased cystogenesis through increased glucose absorption via SGLT1.19 What remains to be seen is whether the kidney protective effects of SGLT2i can offset the decline in eGFR associated with increased cyst volume among patients with ADPKD.