Dual-luciferase reporter gene assays confirmed that suppressor of cytokine signaling 2 (SOCS2) is a direct target of miR-181b and that the miR-181b-5p/SOCS2/JAK2/STAT5 signaling axis promotes the metastasis of HB (Fig. 2). The gene discussed is SOCS2; the disease is hemoglobin measurement.