Cui et al. reported that the upregulation of O-glycosylated La-related protein 1 (LARP1) mediated by circCLNS1A promotes the occurrence and progression of HB through the la-related protein 1 (LARP1)/dickkopf4 (DKK4)/β-catenin axis, with LARP1 and DKK4 being promising therapeutic targets and diagnostic biomarkers for HB [38]. This evidence concerns the gene DKK4 and hemoglobin measurement.