In Ankylosing Spondylitis (AS), enhanced SOCS3 expression in Peripheral Blood Mononuclear Cells (PBMCs), CD4+ T cells, and monocytes show positive correlation with systemic inflammatory markers such as Erythrocyte Sedimentation Rate (ESR) and C-Reactive Protein (CRP), as well as with clinical indices of functional impairment. This evidence concerns the gene CD4 and ankylosing spondylitis.