Moreover, our previous studies have revealed that immune-inflammatory indicators, including the platelet-to-lymphocyte ratio (PLR) (20), systemic immune-inflammation index (SII) (21), systemic inflammation response index (SIRI) (22), and hemoglobin, albumin, lymphocyte and platelet (HALP) (23), were significantly associated with both short- and long-term mortality in hip fracture patients. The gene discussed is ALB; the disease is hip fracture.