However, in AD and other tauopathies, tau becomes hyperphosphorylated, misfolded, and prone to aggregate into paired helical filaments (PHFs) and eventually neurofibrillary tangles (NFTs), one of the histopathological hallmarks of the disease (Maccioni et al., 2010; Kametani and Hasegawa, 2018; Chen and Yu, 2023). Here, MAPT is linked to Alzheimer disease.