MAPT and Alzheimer disease: The tau proteinopathy hypothesis proposes that the primary driver of AD pathology is not amyloid accumulation, but rather the abnormal modification and aggregation of the tau protein, a microtubule-associated protein involved in cytoskeletal stability and axonal transport (Maccioni et al., 2010; Kametani and Hasegawa, 2018; Arnsten et al., 2021; Chen and Yu, 2023).