Pan et al. (2024) demonstrated AKT-mediated rescue of synaptic integrity in AD models, while Yang et al. (2020) highlighted AMPK activation via metabolic modulators. However, neither study incorporated combinatorial paradigms nor assessed glial regulatory cascades. Similarly, Li et al. (2023) and Kong et al. (2024) reported MC-induced neuroregeneration and anti-inflammatory effects, yet they did not integrate these effects with pharmacological interventions or provide deep molecular profiling. Here, AKT1 is linked to Alzheimer disease.