Hutchins belonging to the genus Tripterygium in the Celastraceae family, was studied by Zhaochen Ma et al. According to network analysis, the main network targets of CRT in anti-diabetic kidney disease (DKD) were significantly enriched in the PI3K/AKT/NF-κB pathway, and this pathway may play a central role in regulating the inflammatory responses of various diseases. The gene discussed is AKT1; the disease is diabetic kidney disease.