CD81 and acute myeloid leukemia: To further elucidate the functional importance of CD81+ Erys-derived MIF in AML progression, we generated EpoR-Cre;Miffl/fl (Δ/Δ) mice, in which the Mif gene was primarily deleted in the erythroid lineage, as well as in other hematopoietic lineages (Supplemental Figure 6, A and B) (34).