MIF and acute myeloid leukemia: The robust upregulation of Egln3 in AML cells from the CD81+ Erys coculture group was confirmed, and this upregulation was dependent on the MIF/CD74/mTORC1 regulatory axis, as evidenced by the failure of both Δ/Δ CD81+ Erys and mTORC1 inhibitor to elevate Egln3 expression (Supplemental Figure 8, D–F).