When AML cells composed 60% of the peripheral blood (PB) cells in leukemic mice, we observed a significant reduction in the number of all non-AML hematopoietic lineage cells, including CD45− cells, B220+ B cells, CD4+ T cells, CD8+ T cells, Gr1/CD11b+ myeloid cells, and F4/80+ macrophages, in both the BM (1.2 × 108 vs. 1.3 × 106 cells in control [CTRL] vs. AML, respectively) and liver (4.6 × 108 vs. 7.5 × 107 cells in CTRL vs. AML, respectively) (Supplemental Figure 1B). This evidence concerns the gene CD4 and acute myeloid leukemia.