Pathogenic mutations that render RyR1 channels dysfunctional are linked to malignant hyperthermia (MH) (22), exercise-induced rhabdomyolysis (23), and a wide range of RyR1-related myopathies (RyR1-RMs), including central core disease (CCD) (24). The gene discussed is RYR1; the disease is Malignant hyperthermia.