KIF20A and neoplasm: KIF20A depletion significantly decreased tumor incidence with decreased CSC frequency for sg1 (1:574 in KIF20A-KO vs. 1:101 in control group, P = 0.000637) (Figure 4A), and a similar result was obtained for sg3 (1:277 in KIF20A-KO vs. 1:41 in control group, P = 0.00199) (Figure 4B).