Similar to what is observed in mouse LICs, no obvious inward currents were elicited in CD34+-enriched human LICs at pH 7.4, pH 7.0, and pH 5.0, using whole-cell patch clamping (Figure 7A), which indicated acid-ASIC3 exerted a noncanonical effect on leukemia development. Here, CD34 is linked to leukemia.