Intriguingly, by using an MLL-AF9–induced AML model with Asic1a–/– and Asic3–/– mice, we observed that the frequencies of Asic3-null, but not Asic1a-null, leukemia cells in the peripheral blood (PB) were significantly higher than those in control mice upon primary transplantation (Figure 1, B and C, and Supplemental Figure 1, C and D). Here, ASIC3 is linked to leukemia.