ASIC3 and neoplasm: More importantly, overexpression of these Asic3 mutants in WT AML cells resulted in a notable extended survival of leukemic mice, whereas ectopic activation of Asic3 mutants in Asic3-null AML cells could completely reverse the phenotypes caused by the Asic3 deletion (Figure 3, C and D), indicating Asic3, indeed, exerts its dominant tumor-suppressing effect in a noncanonical manner without inducing a sufficient inward current.