We then knocked down ASIC3 in several human AML samples and demonstrated that the ASIC3-knockdown CD34+ LICs grew much faster compared with scrambled cells (Figure 7, B–D, and Supplemental Figure 11G) and gave rise to more colonies as well as total derived cell numbers (Figure 7, E and F). The gene discussed is ASIC3; the disease is acute myeloid leukemia.