To examine whether MEIS1 is a downstream target of ASIC3, a rescue assay showed that the mice receiving the Meis1-knockdown Asic3-null AML cells succumbed to death much more slowly than did mice transplanted with Asic3-null leukemia cells, as indicated by the reduced leukemia cell frequency and prolonged survival (Figure 4, C and D, and Supplemental Figure 6F). This evidence concerns the gene MEIS1 and leukemia.