To further test the functions of ASIC3 in human AML-LICs, Lin–CD34+CD38–CD90–CD45RA+ LICs and CD34–CD38– leukemia cells were purified for the evaluation of ASIC3 mRNA level by qRT-PCR, which showed that ASIC3 was also expressed in both cell populations, as well as their counterparts of human cord blood HSCs (Supplemental Figure 11, D–F). This evidence concerns the gene ASIC3 and leukemia.