ASIC3 and acute myeloid leukemia: To unravel the roles of ASIC3 in human AML, we determined the mRNA levels of ASIC3 in different subtypes of human AML cell lines by qRT-PCR and found most of them expressed ASIC3, including Kasumi-1 (M2), HL-60 (M3), THP-1 (M5), U937 (M5), and MV4-11 (M5) (Supplemental Figure 10A).