CD34 and leukemia: To further test the functions of ASIC3 in human AML-LICs, Lin–CD34+CD38–CD90–CD45RA+ LICs and CD34–CD38– leukemia cells were purified for the evaluation of ASIC3 mRNA level by qRT-PCR, which showed that ASIC3 was also expressed in both cell populations, as well as their counterparts of human cord blood HSCs (Supplemental Figure 11, D–F).