We measured MEIS1 protein levels in both LICs and the bulk of BM leukemia cells, using Western blotting, and found that the MEIS1 levels were substantially increased in Asic3-null AML cells, especially in Asic3-null LICs (Figure 4B and Supplemental Figure 6D). The gene discussed is ASIC3; the disease is acute myeloid leukemia.