An adenovirus engineered with the human mucin 1 antibody gene and the CD3 receptor—Ad5/3‐E2F‐d24‐aMUC1aCD3 (TILT‐321) replicates only in cells and produces large amounts of aMUC1aCD3 molecules in the tumor microenvironment, which causes tumor cell lysis [171, 172]. This evidence concerns the gene MUC1 and neoplasm.